Computer screen capture, like of ordinary Windows programs (not video/etc)? I'd try turning off deblocking; I'd think that in screen capture it would only have a negative effect due to the large areas of solid color. High subme is definitely useful, along with a strong motion search to catch motion. I'd think multiple reference frames would also be quite useful, along with all partition types, including p4x4. Assuming you don't have to do live encoding, and don't care too much about speed, I'd use: --bime --bframes 16 --weightb --subme 7 --ref 16 --me umh --merange 24 --trellis 1 --b-rdo --partitions all --direct auto --b-pyramid --8x8dct